TY - JOUR UR - http://lib.ugent.be/catalog/pug01:8520630 ID - pug01:8520630 LA - eng TI - Innovative approaches to treat Staphylococcus aureus biofilm-related infections PY - 2017 JO - (2017) Essays in Biochemistry SN - 9781855782051 SN - 0071-1365 PB - London AU - Richter, Katharina AU - Van den Driessche, Freija UGent 000070314387 802001377436 974406001896 0000-0001-9962-3109 AU - Coenye, Tom FW02 801001216803 0000-0002-6407-0601 AU - Venter, H editor AB - Many bacterial infections in humans and animals are caused by bacteria residing in biofilms, complex communities of attached organisms embedded in an extracellular matrix. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. This decreased susceptibility, together with conventional mechanisms leading to antimicrobial resistance, makes biofilm-related infections increasingly difficult to treat and alternative antibiofilm strategies are urgently required. In this review, we present three such strategies to combat biofilm-related infections with the important human pathogen Staphylococcus aureus: (i) targeting the bacterial communication system with quorum sensing (QS) inhibitors, (ii) a 'Trojan Horse' strategy to disturb iron metabolism by using gallium-based therapeutics and (iii) the use of 'non-antibiotics' with antibiofilm activity identified through screening of repurposing libraries. ER -Download RIS file
| 00000nam^a2200301^i^4500 | |||
| 001 | 8520630 | ||
| 005 | 20180917103820.0 | ||
| 008 | 170517s2017------------------------eng-- | ||
| 020 | a 9781855782051 | ||
| 022 | a 0071-1365 | ||
| 024 | a 000396438200006 2 wos | ||
| 024 | a 1854/LU-8520630 2 handle | ||
| 024 | a 10.1042/EBC20160056 2 doi | ||
| 040 | a UGent | ||
| 245 | a Innovative approaches to treat Staphylococcus aureus biofilm-related infections | ||
| 260 | a London, UK b Portland Press c 2017 | ||
| 520 | a Many bacterial infections in humans and animals are caused by bacteria residing in biofilms, complex communities of attached organisms embedded in an extracellular matrix. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. This decreased susceptibility, together with conventional mechanisms leading to antimicrobial resistance, makes biofilm-related infections increasingly difficult to treat and alternative antibiofilm strategies are urgently required. In this review, we present three such strategies to combat biofilm-related infections with the important human pathogen Staphylococcus aureus: (i) targeting the bacterial communication system with quorum sensing (QS) inhibitors, (ii) a 'Trojan Horse' strategy to disturb iron metabolism by using gallium-based therapeutics and (iii) the use of 'non-antibiotics' with antibiofilm activity identified through screening of repurposing libraries. | ||
| 598 | a A1 | ||
| 100 | a Richter, Katharina | ||
| 700 | a Van den Driessche, Freija u UGent 0 000070314387 0 802001377436 0 974406001896 0 0000-0001-9962-3109 | ||
| 700 | a Coenye, Tom u FW02 0 801001216803 0 0000-0002-6407-0601 | ||
| 700 | a Venter, H e editor | ||
| 650 | a Biology and Life Sciences | ||
| 650 | a Medicine and Health Sciences | ||
| 653 | a QUORUM-SENSING INHIBITORS | ||
| 653 | a SEROTONIN REUPTAKE INHIBITORS | ||
| 653 | a TRANSITION-METAL GALLIUM | ||
| 653 | a PSEUDOMONAS-AERUGINOSA | ||
| 653 | a IN-VITRO | ||
| 653 | a ANTIMICROBIAL ACTIVITY | ||
| 653 | a BACTERIAL BIOFILMS | ||
| 653 | a ANTIBACTERIAL COMPOUNDS | ||
| 653 | a HAMAMELITANNIN ANALOGS | ||
| 653 | a ANTIBIOTIC-RESISTANCE | ||
| 773 | t Essays in Biochemistry g Essays Biochem. 2017. Portland Press. 61 (1) p.61-70 q 61:1<61 | ||
| 856 | 3 Full Text u https://biblio.ugent.be/publication/8520630/file/8520631 z [ugent] y innovative_approaches_Saureus.pdf | ||
| 920 | a article | ||
| Z30 | x FW 1 FW02 | ||
| 922 | a UGENT-FW | ||
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