TY - JOUR UR - http://lib.ugent.be/catalog/pug01:203219 ID - pug01:203219 LA - eng TI - Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus PY - 1993 JO - (1993) VACCINE SN - 0264-410X PB - 1993 AU - Vanlandschoot, Peter AU - Maertens, Geert AU - Min Jou, Willy UGent 801000153237 AU - Fiers, Walter UGent 801000033706 AB - Balb/c mice were immunized with 2 x 2 mug of purified recombinant secreted haemagglutinin, derived from the A/Victoria/3/75 (H3N2) virus. In the first immunization, Ribi adjuvant was used, while for the booster injection a monophosphoryl lipid A/muramyl dipeptide combination was chosen. Mice immunized in this way were 90-100% protected against a challenge with 20 LD50 of mouse-adapted, homologous virus (strain X47). Bromelain-solubilized haemagglutinin gave only 70% protection under comparable conditions. ER -Download RIS file
| 00000nam^a2200301^i^4500 | |||
| 001 | 203219 | ||
| 005 | 20180813141336.0 | ||
| 008 | 040114s1993------------------------eng-- | ||
| 022 | a 0264-410X | ||
| 024 | a A1993LZ90800002 2 wos | ||
| 024 | a 1854/LU-203219 2 handle | ||
| 024 | a 10.1016/0264-410X(93)90040-5 2 doi | ||
| 040 | a UGent | ||
| 245 | a Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus | ||
| 246 | a Recombinant secreted hemagglutinin protects mice against a lethal challenge of influenza virus | ||
| 260 | c 1993 | ||
| 520 | a Balb/c mice were immunized with 2 x 2 mug of purified recombinant secreted haemagglutinin, derived from the A/Victoria/3/75 (H3N2) virus. In the first immunization, Ribi adjuvant was used, while for the booster injection a monophosphoryl lipid A/muramyl dipeptide combination was chosen. Mice immunized in this way were 90-100% protected against a challenge with 20 LD50 of mouse-adapted, homologous virus (strain X47). Bromelain-solubilized haemagglutinin gave only 70% protection under comparable conditions. | ||
| 598 | a A1 | ||
| 700 | a Vanlandschoot, Peter 0 801000900440 9 74B198FC-B25E-11E6-B104-2D2FD0AF0289 | ||
| 700 | a Maertens, Geert | ||
| 700 | a Min Jou, Willy u UGent 0 801000153237 0 976164358383 9 F33F9A8E-F0ED-11E1-A9DE-61C894A0A6B4 | ||
| 700 | a Fiers, Walter u UGent 0 801000033706 0 811000033787 9 FC58B20E-F0ED-11E1-A9DE-61C894A0A6B4 | ||
| 650 | a Biology and Life Sciences | ||
| 653 | a HEMAGGLUTININ | ||
| 653 | a INFLUENZA VIRUS | ||
| 653 | a RECOMBINANT | ||
| 653 | a PROTECTION | ||
| 653 | a RIBI ADJUVANT | ||
| 653 | a VACCINE | ||
| 653 | a A H1N1 | ||
| 653 | a HEMAGGLUTININ | ||
| 653 | a GENE | ||
| 653 | a HA | ||
| 773 | t VACCINE g Vaccine. 1993. 11 (12) p.1185-1187 q 11:12<1185 | ||
| 856 | 3 Full Text u https://biblio.ugent.be/publication/203219/file/938475 z [ugent] y 0777_93Vanlandschoot.pdf | ||
| 920 | a article | ||
| Z30 | x WE 1 WE14 | ||
| 922 | a UGENT-WE | ||
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