TY - BOOK UR - http://lib.ugent.be/catalog/ebk01:3710000000902943 ID - ebk01:3710000000902943 LA - eng TI - Systems Biology of Tumor Microenvironment Quantitative Modeling and Simulations PY - 2016 SN - 9783319420233 AU - Rejniak, Katarzyna A. editor. AB - Foreword -- Preface -- List of Contributors -- Image Analysis of the Tumor Microenvironment -- Hypoxia in Gliomas: Opening Therapeutical Opportunities Using a Mathematical-Based Approach -- Computer Simulations of the Tumor Vasculature: Applications to Interstitial Fluid Flow, Drug Delivery, and Oxygen -- Cell-ECM Interactions in Tumor Invasion -- Circulating Tumor Cells: When Solid tumor Meets Fluid Microenvironment -- Modeling Proteolytically Driven Tumor Lymphangiogenesis -- Positive feedback loops between inflammatory, bone and cancer cells during metastatic niche construction -- Microenvironmental Niches and Sanctuaries: a Route to Acquired Resistance -- The Tumor Microenvironment as a Barrier to Cancer Nanotherapy -- Microenvironment-Mediated Modeling of Tumor Response to Vascular-Targeting Drugs -- Optimizing Chemotherapeutic Anti-Cancer Treatment and the Tumor Microenvironment: An Analysis of Mathematical Models -- Progress towards computational 3-D multicellular systems biology -- Index. AB - This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology. ER -Download RIS file
03934nam a22004575i 4500 | |||
001 | 978-3-319-42023-3 | ||
003 | DE-He213 | ||
005 | 20161013161531.0 | ||
007 | cr nn 008mamaa | ||
008 | 161013s2016 gw | s |||| 0|eng d | ||
020 | a 9783319420233 9 978-3-319-42023-3 | ||
024 | 7 | a 10.1007/978-3-319-42023-3 2 doi | |
050 | 4 | a RC261-271 | |
072 | 7 | a MJCL 2 bicssc | |
072 | 7 | a MED062000 2 bisacsh | |
082 | 4 | a 614.5999 2 23 | |
245 | 1 | a Systems Biology of Tumor Microenvironment h [electronic resource] : b Quantitative Modeling and Simulations / c edited by Katarzyna A. Rejniak. | |
264 | 1 | a Cham : b Springer International Publishing : b Imprint: Springer, c 2016. | |
300 | a XVII, 249 p. 93 illus., 80 illus. in color. b online resource. | ||
336 | a text b txt 2 rdacontent | ||
337 | a computer b c 2 rdamedia | ||
338 | a online resource b cr 2 rdacarrier | ||
347 | a text file b PDF 2 rda | ||
490 | 1 | a Advances in Experimental Medicine and Biology, x 0065-2598 ; v 936 | |
505 | a Foreword -- Preface -- List of Contributors -- Image Analysis of the Tumor Microenvironment -- Hypoxia in Gliomas: Opening Therapeutical Opportunities Using a Mathematical-Based Approach -- Computer Simulations of the Tumor Vasculature: Applications to Interstitial Fluid Flow, Drug Delivery, and Oxygen -- Cell-ECM Interactions in Tumor Invasion -- Circulating Tumor Cells: When Solid tumor Meets Fluid Microenvironment -- Modeling Proteolytically Driven Tumor Lymphangiogenesis -- Positive feedback loops between inflammatory, bone and cancer cells during metastatic niche construction -- Microenvironmental Niches and Sanctuaries: a Route to Acquired Resistance -- The Tumor Microenvironment as a Barrier to Cancer Nanotherapy -- Microenvironment-Mediated Modeling of Tumor Response to Vascular-Targeting Drugs -- Optimizing Chemotherapeutic Anti-Cancer Treatment and the Tumor Microenvironment: An Analysis of Mathematical Models -- Progress towards computational 3-D multicellular systems biology -- Index. | ||
520 | a This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology. | ||
650 | a Medicine. | ||
650 | a Cancer research. | ||
650 | a Biomathematics. | ||
650 | 1 | 4 | a Biomedicine. |
650 | 2 | 4 | a Cancer Research. |
650 | 2 | 4 | a Mathematical and Computational Biology. |
650 | 2 | 4 | a Biological and Medical Physics, Biophysics. |
700 | 1 | a Rejniak, Katarzyna A. e editor. | |
710 | 2 | a SpringerLink (Online service) | |
773 | t Springer eBooks | ||
776 | 8 | i Printed edition: z 9783319420219 | |
830 | a Advances in Experimental Medicine and Biology, x 0065-2598 ; v 936 | ||
856 | 4 | u http://dx.doi.org/10.1007/978-3-319-42023-3 | |
912 | a ZDB-2-SBL | ||
950 | a Biomedical and Life Sciences (Springer-11642) |
All data below are available with an Open Data Commons Open Database License. You are free to copy, distribute and use the database; to produce works from the database; to modify, transform and build upon the database. As long as you attribute the data sets to the source, publish your adapted database with ODbL license, and keep the dataset open (don't use technical measures such as DRM to restrict access to the database).
The datasets are also available as weekly exports.